Abstract
The oocyte is a highly differentiated cell. It makes organelles specialized to its unique functions and progresses through a series of developmental stages to acquire a fertilization competent phenotype. This review will integrate the biology of the oocyte with what is known about oocyte-specific gene regulation and transcription factors involved in oocyte development. We propose that oogenesis is reliant on a dynamic gene regulatory network that includes oocyte-specific transcriptional regulators.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Female
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Gene Expression Regulation, Developmental*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Octamer Transcription Factor-3
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Oocytes / physiology*
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Oogenesis / physiology
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Organ Specificity
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Ovary / growth & development
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Ovum / physiology*
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Pregnancy
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RNA, Ribosomal / genetics
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RNA, Ribosomal / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription, Genetic*
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Xenopus Proteins / genetics
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Xenopus Proteins / metabolism
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Figla protein, mouse
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GTF2A1L protein, Xenopus
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Homeodomain Proteins
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Octamer Transcription Factor-3
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Og2x protein, mouse
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POU5F1 protein, human
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RNA, Ribosomal
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Transcription Factors
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Xenopus Proteins
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oogenesin protein, mouse