Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

Göran Landberg; Kristina Nilsson; Karin Jirström; Lisa Rydén; Richard Kitching; Angelika M Burger; Arun Seth

doi:10.1007/s10549-004-2230-y

Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

Breast Cancer Res Treat. 2005 Feb;89(3):313-6. doi: 10.1007/s10549-004-2230-y.

Authors

Göran Landberg¹, Kristina Nilsson, Karin Jirström, Lisa Rydén, Richard Kitching, Angelika M Burger, Arun Seth

Affiliation

¹ Division of Pathology, Department of Laboratory Medicine, U-MAS, Lund University, Malmö, Sweden.

PMID: 15754132
DOI: 10.1007/s10549-004-2230-y

Abstract

In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Breast Neoplasms / metabolism*
Cyclin I
Cyclins / metabolism*
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Molecular Sequence Data
Neoplasm Invasiveness*
Neovascularization, Pathologic / metabolism
Vascular Endothelial Growth Factor A / metabolism*
Vascular Endothelial Growth Factor Receptor-2 / metabolism*

Substances

CCNI protein, human
Cyclin I
Cyclins
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-2