Analytical methods used to measure acrylamide concentrations in foods

J AOAC Int. 2005 Jan-Feb;88(1):274-84.

Abstract

The state-of-the-art of analysis for acrylamide in food is reviewed. The majority of analytical methods adopts a similar approach: addition of internal standard to the specimen, extraction with water, purification of extract using a solid-phase extraction cartridge, and then determination using either gas chromatography coupled to mass spectroscopy (GC/MS) after bromination, or direct measurement with liquid chromatography coupled to mass spectroscopy (LC/MS). The available methods generally show good agreement and are likely to be accurate. However, improvements in precision (within-laboratory) and repeatability (between-laboratory) are needed by particular data users.

Publication types

  • Review

MeSH terms

  • Acrylamide / chemistry*
  • Acrylamides / chemistry
  • Bromine / chemistry
  • Calibration
  • Chromatography, Gas
  • Chromatography, Liquid
  • Enzyme-Linked Immunosorbent Assay
  • Food
  • Food Analysis / methods*
  • Gas Chromatography-Mass Spectrometry
  • Mass Spectrometry
  • Models, Chemical
  • Sensitivity and Specificity
  • Solvents
  • Time Factors
  • Ultraviolet Rays
  • Water

Substances

  • Acrylamides
  • Solvents
  • Water
  • Acrylamide
  • Bromine