Selective detection of saxitoxin over tetrodotoxin using acridinylmethyl crown ether chemosensor

Toxicon. 2005 May;45(6):783-7. doi: 10.1016/j.toxicon.2005.01.019.

Abstract

At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. These sensors are selective for the detection of saxitoxin over tetrodotoxin.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biosensing Techniques / methods*
  • Chemistry Techniques, Analytical / methods*
  • Chromatography, Gel
  • Coumarins / chemistry
  • Crown Ethers / chemistry*
  • Hydrogen-Ion Concentration
  • Protein Binding
  • Saxitoxin / analysis*
  • Saxitoxin / chemistry
  • Tetrodotoxin / analysis*
  • Tetrodotoxin / chemistry

Substances

  • Coumarins
  • Crown Ethers
  • Saxitoxin
  • Tetrodotoxin
  • coumarin