Linking epithelial-mesenchymal transition to the well-known polarity protein Par6

Jean Paul Thiery; Ruby Huang

doi:10.1016/j.devcel.2005.03.002

Linking epithelial-mesenchymal transition to the well-known polarity protein Par6

Dev Cell. 2005 Apr;8(4):456-8. doi: 10.1016/j.devcel.2005.03.002.

Authors

Jean Paul Thiery¹, Ruby Huang

Affiliation

¹ CNRS UMR 144, Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75248 Paris, Cedex 05, France.

PMID: 15809027
DOI: 10.1016/j.devcel.2005.03.002

Abstract

Epithelial-mesenchymal transition (EMT) is involved in the formation of the body plan, tissue remodeling, and cancer progression. Two recent reports in Science (Barrios-Rodiles et al., 2005; Ozdamar et al., 2005) have decisively advanced our understanding of EMT. Par6 was identified as a key player in the control of tight junction (TJ) stability. This new study provides further insight into the protein networks involved in topologically regulated control of epithelial cell polarity and plasticity.

MeSH terms

Adaptor Proteins, Signal Transducing
Carrier Proteins / metabolism*
Cell Polarity
Epithelial Cells / physiology*
Humans
Mesoderm / cytology
Mesoderm / physiology*
Morphogenesis*
Receptors, Transforming Growth Factor beta / metabolism
Tight Junctions / metabolism

Substances

Adaptor Proteins, Signal Transducing
Carrier Proteins
PARD6A protein, human
Receptors, Transforming Growth Factor beta