Degradation of beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26

Appl Environ Microbiol. 2005 Apr;71(4):2183-5. doi: 10.1128/AEM.71.4.2183-2185.2005.

Abstract

Beta-Hexachlorocyclohexane (beta-HCH) is the most recalcitrant among the alpha-, beta-, gamma-, and delta-isomers of HCH and causes serious environmental pollution problems. We demonstrate here that the haloalkane dehalogenase LinB, reported earlier to mediate the second step in the degradation of gamma-HCH in Sphingomonas paucimobilis UT26, metabolizes beta-HCH to produce 2,3,4,5,6-pentachlorocyclohexanol.

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Biodegradation, Environmental
  • Cyclohexanols / metabolism*
  • Gene Expression Regulation, Bacterial
  • Hexachlorocyclohexane / metabolism*
  • Hydrolases / genetics
  • Hydrolases / metabolism*
  • Sphingomonas / enzymology*
  • Sphingomonas / genetics

Substances

  • 2,3,4,5,6-pentachlorocyclohexanol
  • Bacterial Proteins
  • Cyclohexanols
  • Hexachlorocyclohexane
  • Hydrolases
  • haloalkane dehalogenase
  • beta-hexachlorocyclohexane