Surgery and treatment with high-dose liposomal amphotericin B for eradication of craniofacial zygomycosis in a patient with Hodgkin's disease who had undergone allogeneic hematopoietic stem cell transplantation

J Clin Microbiol. 2005 Apr;43(4):2012-4. doi: 10.1128/JCM.43.4.2012-2014.2005.

Abstract

This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant. Empirical therapy with itraconazole and amoxicillin-clavulanate failed to resolve the infection. Postdiagnosis, surgery and treatment with high-dose liposomal amphotericin B eradicated the disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Facial Pain / etiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hodgkin Disease / therapy
  • Humans
  • Liposomes / therapeutic use
  • Male
  • Mucormycosis* / drug therapy
  • Mucormycosis* / microbiology
  • Mucormycosis* / surgery
  • Rhizopus* / classification
  • Rhizopus* / isolation & purification
  • Sinusitis* / drug therapy
  • Sinusitis* / microbiology
  • Sinusitis* / surgery
  • Transplantation, Homologous / adverse effects*

Substances

  • Antifungal Agents
  • Liposomes
  • liposomal amphotericin B
  • Amphotericin B