Abstract
This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant. Empirical therapy with itraconazole and amoxicillin-clavulanate failed to resolve the infection. Postdiagnosis, surgery and treatment with high-dose liposomal amphotericin B eradicated the disease.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amphotericin B / therapeutic use
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Antifungal Agents / therapeutic use
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Facial Pain / etiology*
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Hodgkin Disease / therapy
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Humans
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Liposomes / therapeutic use
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Male
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Mucormycosis* / drug therapy
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Mucormycosis* / microbiology
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Mucormycosis* / surgery
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Rhizopus* / classification
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Rhizopus* / isolation & purification
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Sinusitis* / drug therapy
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Sinusitis* / microbiology
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Sinusitis* / surgery
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Transplantation, Homologous / adverse effects*
Substances
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Antifungal Agents
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Liposomes
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liposomal amphotericin B
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Amphotericin B