Immunization with recombinant surface antigen P50 of Babesia gibsoni expressed in insect cells induced parasite growth inhibition in dogs

Clin Diagn Lab Immunol. 2005 Apr;12(4):557-9. doi: 10.1128/CDLI.12.4.557-559.2005.

Abstract

This is a report of a vaccine trial directed against Babesia gibsoni infection in dogs with the use of the recombinant antigen P50. Dogs immunized with P50 showed partial protection manifested as a significantly low level of parasitemia. The results indicated that P50 is a primary vaccine candidate molecule against canine B. gibsoni infection.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Protozoan / immunology*
  • Antigens, Protozoan / therapeutic use
  • Antigens, Surface / immunology
  • Babesia / immunology
  • Babesiosis / immunology
  • Babesiosis / prevention & control*
  • Babesiosis / veterinary
  • Blotting, Western / methods
  • Cells, Cultured
  • Dog Diseases / immunology
  • Dog Diseases / parasitology
  • Dog Diseases / prevention & control*
  • Dogs
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay / methods
  • Immunization / methods*
  • Insecta / cytology
  • Insecta / metabolism
  • Recombinant Fusion Proteins / immunology
  • Recombinant Fusion Proteins / therapeutic use
  • Time Factors

Substances

  • Antigens, Protozoan
  • Antigens, Surface
  • Recombinant Fusion Proteins