Abstract
This is a report of a vaccine trial directed against Babesia gibsoni infection in dogs with the use of the recombinant antigen P50. Dogs immunized with P50 showed partial protection manifested as a significantly low level of parasitemia. The results indicated that P50 is a primary vaccine candidate molecule against canine B. gibsoni infection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Protozoan / immunology*
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Antigens, Protozoan / therapeutic use
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Antigens, Surface / immunology
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Babesia / immunology
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Babesiosis / immunology
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Babesiosis / prevention & control*
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Babesiosis / veterinary
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Blotting, Western / methods
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Cells, Cultured
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Dog Diseases / immunology
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Dog Diseases / parasitology
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Dog Diseases / prevention & control*
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Dogs
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Dose-Response Relationship, Drug
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Enzyme-Linked Immunosorbent Assay / methods
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Immunization / methods*
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Insecta / cytology
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Insecta / metabolism
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Recombinant Fusion Proteins / immunology
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Recombinant Fusion Proteins / therapeutic use
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Time Factors
Substances
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Antigens, Protozoan
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Antigens, Surface
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Recombinant Fusion Proteins