Abstract
Quinolone-resistant Streptococcus agalactiae bacteria were recovered from single-patient isolates and found to contain mutations in the gyrase and topoisomerase IV genes. Pulsed-field gel electrophoresis demonstrated that four isolates from the same long-term care facility were closely related; in seven cases, quinolone-resistant Haemophilus influenzae and S. agalactiae bacteria were isolated from the same patient.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Infective Agents / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial* / genetics
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Electrophoresis, Gel, Pulsed-Field
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Female
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Fluoroquinolones / pharmacology*
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Streptococcal Infections / epidemiology*
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Streptococcal Infections / microbiology
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Streptococcus agalactiae / classification
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / genetics
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Streptococcus agalactiae / isolation & purification
Substances
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Anti-Infective Agents
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase