Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas

Ken B Waites; Nipun B Reddy; Donna M Crabb; Lynn B Duffy

doi:10.1128/AAC.49.6.2541-2542.2005

Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas

Antimicrob Agents Chemother. 2005 Jun;49(6):2541-2. doi: 10.1128/AAC.49.6.2541-2542.2005.

Authors

Ken B Waites¹, Nipun B Reddy, Donna M Crabb, Lynn B Duffy

Affiliation

¹ Department of Pathology, WP 230, 619 19th Street South, Birmingham, AL 35249, USA. waites@path.uab.edu

Abstract

Peptide deformylase inhibitor LBM-415 and seven other drugs were tested against Mycoplasma pneumoniae (100 isolates), Mycoplasma hominis (20 isolates), Mycoplasma fermentans (10 isolates), and Ureaplasma species (50 isolates). LBM-415 was active against M. pneumoniae (MICs, <or=0.008 microg/ml). It showed no activity against M. hominis and M. fermentans and modest activity against Ureaplasma spp.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amidohydrolases / antagonists & inhibitors*
Anti-Bacterial Agents / pharmacology*
Humans
Microbial Sensitivity Tests
Mycoplasma / classification
Mycoplasma / drug effects*
Mycoplasma fermentans / drug effects
Mycoplasma hominis / drug effects
Mycoplasma pneumoniae / drug effects
Protease Inhibitors / pharmacology*
Ureaplasma / drug effects*

Substances

Anti-Bacterial Agents
Protease Inhibitors
Amidohydrolases
peptide deformylase