Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns

Karen L Mohlke; Andrew D Skol; Laura J Scott; Timo T Valle; Richard N Bergman; Jaakko Tuomilehto; Michael Boehnke; Francis S Collins; FUSION Study Group

doi:10.1016/j.ymgme.2005.04.011

Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns

Mol Genet Metab. 2005 Aug;85(4):323-7. doi: 10.1016/j.ymgme.2005.04.011.

Authors

Karen L Mohlke¹, Andrew D Skol, Laura J Scott, Timo T Valle, Richard N Bergman, Jaakko Tuomilehto, Michael Boehnke, Francis S Collins; FUSION Study Group

Affiliation

¹ Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA. mohlke@med.unc.edu

PMID: 15936967
DOI: 10.1016/j.ymgme.2005.04.011

Abstract

The SLC2A10 gene encodes a glucose transporter and is located on chromosome 20q13, where evidence has been found for linkage to type 2 diabetes (T2D) in multiple studies. We investigated SLC2A10 as a T2D candidate gene in Finns. We did not confirm the previously reported association between Ala206Thr and fasting insulin and we observed no statistically significant evidence for T2D association with any single marker. We tested haplotypes for association with diabetes-related traits and observed no excess of significant results.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromosomes, Human, Pair 20
Diabetes Mellitus, Type 2 / genetics*
Diabetes Mellitus, Type 2 / metabolism
Finland
Genotype
Glucose Transport Proteins, Facilitative
Humans
Monosaccharide Transport Proteins / genetics*
Monosaccharide Transport Proteins / metabolism
Polymorphism, Single Nucleotide*
Siblings

Substances

Glucose Transport Proteins, Facilitative
Monosaccharide Transport Proteins
SLC2A10 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding