Abstract
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigenic Modulation / genetics*
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CD8-Positive T-Lymphocytes / immunology*
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology
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Evolution, Molecular
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Hepacivirus / genetics
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Hepacivirus / immunology*
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Hepatitis C / immunology*
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Hepatitis C Antigens / genetics
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Hepatitis C Antigens / immunology
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Humans
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Mutation
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Pan troglodytes / genetics
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Pan troglodytes / immunology
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T-Lymphocyte Subsets / immunology*
Substances
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Epitopes, T-Lymphocyte
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Hepatitis C Antigens