A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia

Neurology. 2005 Jun 14;64(11):1949-51. doi: 10.1212/01.WNL.0000163767.99354.C3.

Abstract

A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / drug effects
  • Antibodies / immunology
  • Botulinum Toxins, Type A / administration & dosage*
  • Botulinum Toxins, Type A / adverse effects
  • Botulinum Toxins, Type A / chemistry
  • Disability Evaluation
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Resistance / immunology
  • Humans
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology
  • Neck Muscles / drug effects
  • Neck Muscles / physiopathology
  • Torticollis / drug therapy*
  • Torticollis / physiopathology
  • Treatment Outcome

Substances

  • Antibodies
  • Botulinum Toxins, Type A
  • incobotulinumtoxinA