Individual psychotherapy is a recommended treatment of patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition , cluster B personality disorders. Due to their pathology, these patients represent a challenge in psychotherapy, and guidelines for practical handling exist. This study examined the attitudes of psychotherapists toward these challenges. Three hundred twenty-four experienced Norwegian therapists filled in a questionnaire on issues relevant to individual psychotherapy of patients with personality disorders. The attitudes toward cluster B patients were examined and compared with those of clusters A and C patients on contract issues, acting out, use of drugs, information to relatives, and contraindications. A considerable gap was found between therapists' attitudes toward cluster B patients and published guidelines. The therapists mostly handled cluster B in the same way as clusters A and C. Empirical investigations of therapists' handling provide an important feedback from everyday clinical practice on divergences in relation to guidelines derived from experts' consensus and research.