Abstract
Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Blood Platelets / metabolism*
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Epilepsy, Tonic-Clonic / metabolism*
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Female
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Humans
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Male
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Membrane Glycoproteins / blood*
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Membrane Transport Proteins / blood*
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Middle Aged
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Nerve Tissue Proteins / blood*
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Paroxetine / blood
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Paroxetine / pharmacokinetics
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Seizures / metabolism*
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Selective Serotonin Reuptake Inhibitors / blood
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Selective Serotonin Reuptake Inhibitors / pharmacokinetics
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Serotonin / blood
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Serotonin Plasma Membrane Transport Proteins
Substances
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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Serotonin
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Paroxetine