The SET-domain protein superfamily: protein lysine methyltransferases

Genome Biol. 2005;6(8):227. doi: 10.1186/gb-2005-6-8-227. Epub 2005 Aug 2.

Abstract

The SET-domain protein methyltransferase superfamily includes all but one of the proteins known to methylate histones on lysine. Histone methylation is important in the regulation of chromatin and gene expression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Histone-Lysine N-Methyltransferase / chemistry*
  • Histone-Lysine N-Methyltransferase / classification*
  • Histone-Lysine N-Methyltransferase / genetics
  • Histone-Lysine N-Methyltransferase / metabolism
  • Humans
  • Methylation
  • Models, Molecular
  • Multigene Family*
  • Protein Structure, Tertiary

Substances

  • Histone-Lysine N-Methyltransferase