GMFM 1 year after continuous intrathecal baclofen infusion

Pediatr Rehabil. 2005 Jul-Sep;8(3):207-13. doi: 10.1080/13638490400021479.

Abstract

The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Baclofen / administration & dosage
  • Baclofen / therapeutic use*
  • Cerebral Palsy / physiopathology
  • Cerebral Palsy / prevention & control*
  • Child
  • Child, Preschool
  • Follow-Up Studies
  • Humans
  • Infusion Pumps, Implantable
  • Injections, Spinal
  • Lower Extremity / physiopathology
  • Motor Activity / drug effects*
  • Motor Activity / physiology
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology
  • Muscle Relaxants, Central / administration & dosage
  • Muscle Relaxants, Central / therapeutic use*
  • Muscle Spasticity / physiopathology
  • Muscle Spasticity / prevention & control
  • Patient Satisfaction
  • Physical Endurance / physiology
  • Posture / physiology
  • Prospective Studies

Substances

  • Muscle Relaxants, Central
  • Baclofen