Lymphocytic myocarditis after lung transplantation

J Heart Lung Transplant. 2005 Aug;24(8):1163-5. doi: 10.1016/j.healun.2004.07.012.

Abstract

This study reports the development of lymphocytic myocarditis in a bilateral lung allograft recipient. A 23-year-old woman developed congestive heart failure and severe left ventricular dysfunction 32 months after a bilateral lung allograft for cystic fibrosis. She had taken oral acyclovir for infectious mononucleosis that was diagnosed 11 months previously. Her viral load for Epstein-Barr virus (EBV) increased, and an echocardiogram revealed a left ventricular ejection fraction of 25% and endomyocardial biopsy revealed lymphocytic myocarditis. She received valacyclovir (1 g x 3 times daily) and made a full recovery 6 months later.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / analogs & derivatives
  • Adult
  • Antiviral Agents / administration & dosage
  • Biopsy, Needle
  • Cystic Fibrosis / diagnosis
  • Cystic Fibrosis / surgery
  • Female
  • Follow-Up Studies
  • Heart Failure / etiology*
  • Humans
  • Immunohistochemistry
  • Infectious Mononucleosis / diagnosis
  • Infectious Mononucleosis / drug therapy
  • Infectious Mononucleosis / etiology*
  • Lung Transplantation / adverse effects*
  • Lung Transplantation / methods
  • Lymphocytes / pathology
  • Myocarditis / drug therapy*
  • Myocarditis / etiology*
  • Myocarditis / pathology
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome
  • Valacyclovir
  • Valine / administration & dosage
  • Valine / analogs & derivatives

Substances

  • Antiviral Agents
  • Valine
  • Valacyclovir
  • Acyclovir