The genetic and environmental contributions to oppositional defiant behavior: a multi-informant twin study

J Am Acad Child Adolesc Psychiatry. 2005 Sep;44(9):907-14. doi: 10.1097/01.chi.0000169011.73912.27.

Abstract

Objective: To estimate the genetic and environmental contributions to oppositional defiant behavior (ODB) from mother, father, and teacher report using the Conners Revised Short Forms in a large twin sample.

Method: ODB data were collected from 1,595 mothers, 1,114 fathers, and 793 teachers of 7-year-old twin pairs from the Netherlands Twin Registry in the 1990-1992 cohort with an 80% response rate. Models were fit for each informant to determine the genetic, environmental, gender, and informant influences on ODB.

Results: Genetic analyses of the ODB quantitative scale showed additive genetic (A) by mother (55%), by father (57%), and by teacher (21% girls, 38% boys) unique environmental (E) (mother, 22%; father, 29%; teacher, 48% girls, 39% boys) and shared environmental (C) (mother, 14%; father, 23%; teacher, 31% girls, 23% boys) influences.

Conclusions: Additive genetic and unique environmental factors account for the majority of the influences on ODB for boys and girls by all informants.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Twin Study

MeSH terms

  • Attention Deficit and Disruptive Behavior Disorders / diagnosis*
  • Attention Deficit and Disruptive Behavior Disorders / epidemiology
  • Attention Deficit and Disruptive Behavior Disorders / genetics*
  • Child
  • Faculty / statistics & numerical data
  • Fathers / statistics & numerical data
  • Female
  • Gene Expression / genetics
  • Humans
  • Male
  • Mothers / statistics & numerical data
  • Netherlands
  • Observer Variation
  • Phenotype*
  • Social Environment*
  • Twins, Dizygotic
  • Twins, Monozygotic
  • United States