Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms

Br J Cancer. 2005 Oct 3;93(7):811-6. doi: 10.1038/sj.bjc.6602762.

Abstract

A population-based case-control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over 30 kg m(-2) at five years before diagnosis,, was associated with an increased risk of NHL (OR = 1.5, 95% CI 1.1-2.1). The excess was most pronounced for diffuse large B-cell lymphoma (OR = 1.9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL risk, as well as a polymorphism in the energy regulatory gene adiponectin (APM1 276G>T), were investigated. Findings varied with leptin genotype, the risks being decreased with LEP 19AA (OR = 0.7, 95% CI 0.5-1.0) and increased with LEP -2548GA (OR = 1.3, 95% CI 1.0-1.7) and -2548AA (OR = 1.4, 95% CI 1.0-1.9), particularly for follicular lymphoma. These genetic findings, which were independent of BMI, were stronger for men than women.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Base Sequence
  • Case-Control Studies
  • DNA Primers
  • Energy Metabolism
  • Homeostasis / genetics*
  • Humans
  • Leptin / genetics
  • Lymphoma, Non-Hodgkin / complications
  • Lymphoma, Non-Hodgkin / genetics*
  • Lymphoma, Non-Hodgkin / metabolism
  • Middle Aged
  • Obesity / complications*
  • Polymorphism, Genetic*
  • Receptors, Cell Surface / genetics
  • Receptors, Leptin

Substances

  • DNA Primers
  • Leptin
  • Receptors, Cell Surface
  • Receptors, Leptin