Overweight and obesity in deltaF508 homozygous cystic fibrosis

J Pediatr. 2005 Sep;147(3):402-4. doi: 10.1016/j.jpeds.2005.06.003.

Abstract

Overweight (9%) and obesity (1%) in patients with cystic fibrosis homozygous for the deltaF508 mutation (CFdeltaF508) were non-trivial. Children with CFdeltaF508, in contrast to the general population, showed a positive association between body mass index and lung function for all body mass index z-scores.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Body Mass Index
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / physiopathology*
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
  • Female
  • Forced Expiratory Volume
  • Homozygote
  • Humans
  • Infant
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Nutritional Status
  • Obesity / complications*
  • Obesity / physiopathology*

Substances

  • CFTR protein, human
  • cystic fibrosis transmembrane conductance regulator delta F508
  • Cystic Fibrosis Transmembrane Conductance Regulator