Abstract
In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Daptomycin / pharmacology*
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Drug Synergism
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Drug Therapy, Combination
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Enterococcus faecium / drug effects*
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Linezolid
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Microbial Sensitivity Tests
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Oxazolidinones / pharmacology
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Rifampin / pharmacology*
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Vancomycin Resistance* / genetics
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid
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Daptomycin
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Rifampin