In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin

Antimicrob Agents Chemother. 2005 Dec;49(12):5166-8. doi: 10.1128/AAC.49.12.5166-5168.2005.

Abstract

In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Daptomycin / pharmacology*
  • Drug Synergism
  • Drug Therapy, Combination
  • Enterococcus faecium / drug effects*
  • Linezolid
  • Microbial Sensitivity Tests
  • Oxazolidinones / pharmacology
  • Rifampin / pharmacology*
  • Vancomycin Resistance* / genetics

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid
  • Daptomycin
  • Rifampin