Abstract
The role of D(1)-like [D(1), D(5)] and D(2)-like [D(2), D(3), D(4)] dopamine receptors and dopamine transduction via DARPP-32 in topographies of orofacial movement was assessed in restrained mice with congenic D(4) vs. D(5) receptor vs. DARPP-32 'knockout'. D(4) and DARPP-32 mutants evidenced no material phenotype; also, there were no alterations in topographical responsivity to either the selective D(2)-like agonist RU 24213 or the selective D(1)-like agonist SK and F 83959. In contrast, D(5) mutants evidenced an increase in spontaneous vertical jaw movements, which habituated more slowly than in wildtypes, and a decrease in horizontal jaw movements; topographical responsivity to SK and F 83959 and RU 24213 was unaltered. D(5) receptors regulate distinct topographies of vertical and horizontal jaw movement in an opposite manner. In assuming that the well-recognised role of the D(1)-like family in regulating orofacial movements involves primarily D(1) receptors, a role for their D(5) counterparts may have been overlooked.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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Animals
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Chromans / pharmacology
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Dopamine and cAMP-Regulated Phosphoprotein 32 / deficiency
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Dopamine and cAMP-Regulated Phosphoprotein 32 / genetics*
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Dyskinesia, Drug-Induced / genetics*
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Dyskinesia, Drug-Induced / physiopathology
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Mice
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Mice, Congenic
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Mice, Inbred C57BL
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Mice, Knockout
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Receptors, Dopamine D4 / agonists
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Receptors, Dopamine D4 / deficiency
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Receptors, Dopamine D4 / genetics*
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Receptors, Dopamine D5 / agonists
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Receptors, Dopamine D5 / deficiency
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Receptors, Dopamine D5 / genetics*
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Signal Transduction / drug effects
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Signal Transduction / genetics*
Substances
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Chromans
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Dopamine and cAMP-Regulated Phosphoprotein 32
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Drd4 protein, mouse
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Ppp1r1b protein, mouse
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Receptors, Dopamine D4
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Receptors, Dopamine D5
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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SK&F 83959
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A 68930