Certainly can't live without this: SIRT6

Joseph T Rodgers; Pere Puigserver

doi:10.1016/j.cmet.2006.01.009

Certainly can't live without this: SIRT6

Cell Metab. 2006 Feb;3(2):77-8. doi: 10.1016/j.cmet.2006.01.009.

Authors

Joseph T Rodgers¹, Pere Puigserver

Affiliation

¹ Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

PMID: 16459306
DOI: 10.1016/j.cmet.2006.01.009

Abstract

Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.

Publication types

Comparative Study

MeSH terms

Aging / metabolism*
Aging / pathology
Animals
DNA Repair / physiology*
Genomic Instability / physiology*
Histone Deacetylases / metabolism
Longevity
Mice
Models, Biological
Phenotype*
Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism
Sirtuin 2
Sirtuins / metabolism*
Yeasts

Substances

Silent Information Regulator Proteins, Saccharomyces cerevisiae
Sirt6 protein, mouse
SIR2 protein, S cerevisiae
Sirtuin 2
Sirtuins
Histone Deacetylases