Synthesis and preliminary in vitro evaluation of 5'-O-esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with alpha-lipoic acid as potential prodrugs

Acta Pol Pharm. 2005 Sep-Oct;62(5):411-5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antioxidants / pharmacology*
  • Cell Line, Tumor
  • Chromatography, High Pressure Liquid
  • Cladribine / chemical synthesis
  • Cladribine / pharmacology*
  • Deoxyadenosines / chemical synthesis
  • Deoxyadenosines / pharmacology*
  • Humans
  • Hydrolysis
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Prodrugs / chemical synthesis
  • Prodrugs / pharmacology*
  • Thioctic Acid / pharmacology*

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Deoxyadenosines
  • Prodrugs
  • Cladribine
  • Thioctic Acid
  • 2'-deoxyadenosine