Abstract
The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / immunology
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Antigens, Bacterial / metabolism*
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Bacterial Outer Membrane Proteins / chemistry
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Bacterial Outer Membrane Proteins / immunology
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / chemistry
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Bacterial Proteins / immunology
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Bacterial Proteins / metabolism*
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Blood Proteins / metabolism*
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Borrelia burgdorferi / chemistry*
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Complement Factor H / metabolism*
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Lipoproteins / chemistry
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Lipoproteins / immunology
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Lipoproteins / metabolism*
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Lyme Disease / immunology*
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Lyme Disease / metabolism
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Blood Proteins
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Lipoproteins
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OspE protein, Borrelia burgdorferi
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Complement Factor H