Abstract
In women with polycystic ovary syndrome, C-reactive protein levels and D-dimer, antithrombin III, activated protein C resistance, and activated partial thromboplastin time were unaffected by metformin treatment throughout pregnancy. Protein C levels increased slightly in the metformin group compared with the placebo group.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Activated Protein C Resistance / epidemiology
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Adult
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Antithrombin III / metabolism
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Blood Coagulation / drug effects*
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C-Reactive Protein / metabolism*
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Female
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Fibrin Fibrinogen Degradation Products / metabolism
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Humans
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Hypoglycemic Agents / therapeutic use*
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Incidence
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Metformin / therapeutic use*
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Partial Thromboplastin Time
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Polycystic Ovary Syndrome / blood*
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Polycystic Ovary Syndrome / drug therapy
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Pregnancy
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Pregnancy Complications / blood*
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Pregnancy Complications / drug therapy
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Pregnancy Outcome*
Substances
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Fibrin Fibrinogen Degradation Products
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Hypoglycemic Agents
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Antithrombin III
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C-Reactive Protein
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Metformin