Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)

Hege Vangstein Aamot; Geir E Tjønnfjord; Jan Delabie; Sverre Heim

doi:10.1016/j.cancergencyto.2005.08.012

Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)

Cancer Genet Cytogenet. 2006 Mar;165(2):172-5. doi: 10.1016/j.cancergencyto.2005.08.012.

Authors

Hege Vangstein Aamot¹, Geir E Tjønnfjord, Jan Delabie, Sverre Heim

Affiliation

¹ Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway.

PMID: 16527613
DOI: 10.1016/j.cancergencyto.2005.08.012

Abstract

We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32. G-banding analysis showed, in addition to multiple other chromosome abnormalities, a del(11)(q13) and addition of unknown material to chromosome arms 13p and 21p. The two latter rearrangements were revealed, by use of multicolor in situ hybridization (M-FISH) analysis, to be a der(13)(qter-->p11::14q32::11q13-->11q22::14q32-->14q11::11q22-->11qter) and a similar der(21)(qter-->p11::14q32::11q13-->11q23::14q32-->14q11::11q22-->11qter). FISH with locus-specific probes for BCL1 and IGH showed a fusion signal on both derivative chromosomes.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Banding
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 14*
Humans
In Situ Hybridization
Karyotyping
Leukemia / genetics*
Lymphoma, Mantle-Cell / genetics*
Male
Middle Aged
Translocation, Genetic*