Prenatal cocaine exposure: an examination of childhood externalizing and internalizing behavior problems at age 7 years

Epidemiol Psichiatr Soc. 2006 Jan-Mar;15(1):20-9.

Abstract

Aim: This study examines the relationship between prenatal cocaine exposure and parent-reported child behavior problems at age 7 years.

Methods: Data are from 407 African-American children (210 cocaine-exposed, 197 non-cocaine-exposed) enrolled prospectively at birth in a longitudinal study on the neurodevelopmental consequences of in utero exposure to cocaine. Prenatal cocaine exposure was assessed at delivery through maternal self-report and bioassays (maternal and infant urine and infant meconium). The Achenbach Child Behavior Checklist (CBCL), a measure of childhood externalizing and internalizing behavior problems, was completed by the child's current primary caregiver during an assessment visit scheduled when the child was seven years old.

Results: Structural equation and GLM/GEE models disclosed no association linking prenatal cocaine exposure status or level of cocaine exposure to child behavior (CBCL Externalizing and Internalizing scores or the eight CBCL subscale scores).

Conclusions: This evidence, based on standardized ratings by the current primary caregiver, fails to support hypothesized cocaine-associated behavioral problems in school-aged children with in utero cocaine exposure. A next step in this line of research is to secure standardized ratings from other informants (e.g., teachers, youth self-report).

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Birth Weight
  • Black or African American
  • Caregivers
  • Child
  • Child Behavior Disorders / diagnosis
  • Child Behavior Disorders / epidemiology*
  • Cocaine / adverse effects*
  • Data Interpretation, Statistical
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Longitudinal Studies
  • Male
  • Mothers
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Prospective Studies
  • Risk Factors
  • Socioeconomic Factors
  • Time Factors

Substances

  • Cocaine