Abstract
This study examined regional changes in rat brain mRNA levels encoding 5-HT(2A) and 5-HT(2C) receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT(2A) receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT(2C) receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT(2A) receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Analysis of Variance
-
Animals
-
Benzodiazepines / pharmacology
-
Brain / drug effects
-
Brain / metabolism*
-
Down-Regulation / drug effects
-
Female
-
Gene Expression Regulation / drug effects*
-
Olanzapine
-
RNA, Messenger / drug effects
-
RNA, Messenger / metabolism*
-
Random Allocation
-
Rats
-
Rats, Sprague-Dawley
-
Receptor, Serotonin, 5-HT2A / drug effects
-
Receptor, Serotonin, 5-HT2A / genetics
-
Receptor, Serotonin, 5-HT2A / metabolism*
-
Receptor, Serotonin, 5-HT2C / drug effects
-
Receptor, Serotonin, 5-HT2C / genetics
-
Receptor, Serotonin, 5-HT2C / metabolism*
-
Selective Serotonin Reuptake Inhibitors / pharmacology*
Substances
-
RNA, Messenger
-
Receptor, Serotonin, 5-HT2A
-
Receptor, Serotonin, 5-HT2C
-
Serotonin Uptake Inhibitors
-
Benzodiazepines
-
Olanzapine