Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain

Behav Brain Res. 2006 Aug 10;171(2):355-62. doi: 10.1016/j.bbr.2006.03.040. Epub 2006 May 22.

Abstract

This study examined regional changes in rat brain mRNA levels encoding 5-HT(2A) and 5-HT(2C) receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT(2A) receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT(2C) receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT(2A) receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Benzodiazepines / pharmacology
  • Brain / drug effects
  • Brain / metabolism*
  • Down-Regulation / drug effects
  • Female
  • Gene Expression Regulation / drug effects*
  • Olanzapine
  • RNA, Messenger / drug effects
  • RNA, Messenger / metabolism*
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Serotonin, 5-HT2A / drug effects
  • Receptor, Serotonin, 5-HT2A / genetics
  • Receptor, Serotonin, 5-HT2A / metabolism*
  • Receptor, Serotonin, 5-HT2C / drug effects
  • Receptor, Serotonin, 5-HT2C / genetics
  • Receptor, Serotonin, 5-HT2C / metabolism*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*

Substances

  • RNA, Messenger
  • Receptor, Serotonin, 5-HT2A
  • Receptor, Serotonin, 5-HT2C
  • Serotonin Uptake Inhibitors
  • Benzodiazepines
  • Olanzapine