Do antidepressants cure or create abnormal brain states?

PLoS Med. 2006 Jul;3(7):e240. doi: 10.1371/journal.pmed.0030240.

Abstract

Moncrieff and Cohen argue that psychotropic drugs create abnormal states that may co-incidentally relieve symptoms of mental illness.

MeSH terms

  • Affect / drug effects
  • Animals
  • Antidepressive Agents / classification
  • Antidepressive Agents / pharmacology*
  • Antidepressive Agents / therapeutic use
  • Biogenic Monoamines / metabolism*
  • Brain Chemistry / drug effects*
  • Cognition / drug effects
  • Depressive Disorder / drug therapy
  • Depressive Disorder / physiopathology
  • Depressive Disorder / psychology
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Humans
  • Models, Neurological*
  • Models, Psychological*
  • Motor Activity / drug effects
  • Randomized Controlled Trials as Topic
  • Receptors, Neurotransmitter / drug effects
  • Severity of Illness Index
  • Sleep / drug effects
  • Treatment Outcome

Substances

  • Antidepressive Agents
  • Biogenic Monoamines
  • Receptors, Neurotransmitter