Abstract
We report 2 sisters with hyper-IgE syndrome treated with daily suppressive dosages of linezolid (LZD) who developed LZD-resistant Staphylococcus aureus carrying the G2576T mutation in the 23S rRNA gene. Molecular typing suggested transmission of the resistant strain from one sister to the other. LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy.
Publication types
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Case Reports
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Research Support, N.I.H., Intramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetamides / administration & dosage*
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Adolescent
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Child
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Disease Susceptibility
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Resistance, Bacterial*
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Female
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Follow-Up Studies
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Humans
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Immunocompromised Host*
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Job Syndrome / diagnosis
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Job Syndrome / immunology*
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Linezolid
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Microbial Sensitivity Tests
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Oxazolidinones / administration & dosage*
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Risk Assessment
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Siblings
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Staphylococcal Infections / diagnosis
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / isolation & purification
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Treatment Outcome
Substances
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Acetamides
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Oxazolidinones
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Linezolid