[Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population]

Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):43-6.
[Article in Chinese]

Abstract

Objective: This case-control study was designed to detect the association between STK15 Phe31Ile polymorphism and colorectal cancer.

Methods: Genotypes were determined in 283 patients with colorectal cancer and 283 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.

Results: The frequency of the STK15 Ile/Ile genotype was significantly higher in cancer cases than in controls (50.2% vs. 36.8%; P = 0.02). Subjects with the Ile/Ile genotype had an increased risk for the occurrence of colorectal cancer compared with those with the STK15 Phe/Phe genotype (adjusted OR, 1.92; 95% CI, 1.13 - 3.27). No significant association was observed between this STK15 polymorphism and risk of metastasis of the cancer.

Conclusion: These findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amino Acid Substitution
  • Aurora Kinase A
  • Aurora Kinases
  • Case-Control Studies
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Confidence Intervals
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Protein Serine-Threonine Kinases / genetics*
  • Protein Serine-Threonine Kinases / metabolism
  • Rectal Neoplasms / enzymology
  • Rectal Neoplasms / genetics*
  • Rectal Neoplasms / pathology
  • Risk Factors

Substances

  • AURKA protein, human
  • Aurora Kinase A
  • Aurora Kinases
  • Protein Serine-Threonine Kinases