B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

Vítor Trovisco; Paula Soares; Manuel Sobrinho-Simões

doi:10.1016/j.humpath.2006.03.013

B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

Hum Pathol. 2006 Jul;37(7):781-6. doi: 10.1016/j.humpath.2006.03.013.

Authors

Vítor Trovisco¹, Paula Soares, Manuel Sobrinho-Simões

Affiliation

¹ IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, 4200 Porto, Portugal.

PMID: 16784975
DOI: 10.1016/j.humpath.2006.03.013

Abstract

The very recent discovery of B-RAF point mutations as the most prevalent genetic alteration in papillary thyroid carcinoma has revolutionized the molecular knowledge of thyroid malignancies. In this review, we address the role played by such mutations in the etiopathogenesis, diagnosis, prognosis, and therapy selection of thyroid cancer, with an emphasis on papillary carcinoma.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinoma, Papillary / diagnosis*
Carcinoma, Papillary / genetics*
Humans
Point Mutation
Prognosis
Proto-Oncogene Proteins B-raf / genetics*
Thyroid Neoplasms / diagnosis*
Thyroid Neoplasms / genetics*

Substances

BRAF protein, human
Proto-Oncogene Proteins B-raf