Patients with neurophakomatoses were not always considered to be candidates for surgical resection of epileptogenic foci, given the multifocal nature of their disease. Advances in imaging, monitoring, and surgical technique have allowed the identification of particularly active areas of cortex that may provide these patients with better seizure control than medications alone. Options for surgical resection range from focal resections (in those with localized disease) to hemispherectomies (in those with hemispheric involvement).