Ultra-sensitive and quantitative characterization of proteomes

Mol Biosyst. 2006 May;2(5):221-30. doi: 10.1039/b601468b. Epub 2006 Apr 6.

Abstract

Electrospray ionization mass spectrometry combined with high efficiency capillary liquid chromatography provides high sensitivity and broad dynamic range measurements for the characterization of biological macromolecules in complex matrices, and is an increasingly powerful analytical tool for systems biology research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatography, Liquid / methods
  • Combinatorial Chemistry Techniques / methods
  • Gas Chromatography-Mass Spectrometry / methods
  • Humans
  • Models, Biological
  • Proteomics / methods*
  • Shewanella / chemistry
  • Spectrometry, Mass, Electrospray Ionization / methods