During the past few years numerous cases of osteonecrosis of the jaws in patients receiving bisphosphonate therapy were published in the literature. In most cases, the osteonecrosis was diagnosed following dento-alveolar surgery, especially following extraction of teeth. To date, no efficient therapy is available and most efforts are geared towards prevention. The propose of the present review is to inform the Israeli dental community about osteonecrosis of the jaws in patients receiving bisphosphonate therapy and to suggest strategies for prevention.