Abstract
This paper presents an ongoing study of children with chronic ITP in Sweden that addresses four specific questions: is there a subgroup of children with chronic ITP that have impaired platelet function? Do children in this subgroup have antibodies directed against surface glycoproteins that are crucial for platelet function? Can desmopressin improve the impaired platelet function in this subgroup? Do children with chronic ITP show signs of cell-mediated cytotoxicity?
Copyright (c) 2006 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Autoantibodies / blood
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Blood Platelets / immunology
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Child
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Chronic Disease
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Deamino Arginine Vasopressin / therapeutic use
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Humans
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Immunity, Cellular
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Membrane Glycoproteins / immunology
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Platelet Adhesiveness / drug effects
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Platelet Aggregation / drug effects
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Platelet Function Tests
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Purpura, Thrombocytopenic, Idiopathic / drug therapy
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Purpura, Thrombocytopenic, Idiopathic / epidemiology
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Purpura, Thrombocytopenic, Idiopathic / immunology*
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Sweden / epidemiology
Substances
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Autoantibodies
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Membrane Glycoproteins
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Deamino Arginine Vasopressin