Mitral regurgitation is a disease associated with major clinical impairment depending on its severity. Treatment is usually performed by surgical reconstruction or valve replacement. Initial attempts to perform the surgical procedure without extracorporeal circulation are currently being made. In parallel, new devices in interventional cardiology offer percutaneous treatment of the disease. At present, one surgical approach and several percutaneous ones exist, which are evaluated in phase I or phase II studies. In this article, the authors focus on the available data as well as on the advantages and disadvantages of the different approaches.