Direct high-resolution peptide and protein analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

Rapid Commun Mass Spectrom. 2006;20(22):3409-11. doi: 10.1002/rcm.2759.

Abstract

We report the first coupling of a desorption electrospray ionization (DESI) ion source to Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR-MS) for high-resolution protein analysis. The DESI FT-ICR-MS source design is described in detail along with preliminary data obtained on peptides and proteins ranging from 1 to 5.7 kDa.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bradykinin / analysis
  • Formates / analysis
  • Glucagon / analysis
  • Insulin / analysis
  • Melitten / analysis
  • Peptides / analysis*
  • Proteins / analysis*
  • Spectrometry, Mass, Electrospray Ionization / methods*
  • Spectroscopy, Fourier Transform Infrared*
  • Vasodilator Agents / analysis

Substances

  • Formates
  • Insulin
  • Peptides
  • Proteins
  • Vasodilator Agents
  • formic acid
  • Melitten
  • Glucagon
  • Bradykinin