Abstract
Neuropeptide Y is released together with norepinephrine from sympathetic nerve terminals during conditions of increased sympathetic activity. Neuropeptide Y is known to inhibit vagal activity, and accordingly, it might increase the risk for ventricular fibrillation during myocardial ischemia-reperfusion, with concomitant sympathetic stimulation. Counteracting the inhibiting effect of neuropeptide Y by the specific neuropeptide Y2 antagonist, BIIE0246, we expected occurrence of ventricular fibrillation in association with repeated periods of myocardial ischemia-reperfusion to decrease. The midleft anterior descending coronary artery was repeatedly occluded in 16 open-chest pigs. Eight pigs received BIIE0246, and the controls received the vehicle only. Ventricular fibrillation developed in 2 animals of the control group, but in 4 pigs receiving BIIE0246. Occurrence of ventricular fibrillation and ventricular tachycardia did not differ significantly between the 2 groups, and in association with repeated periods of regional myocardial ischemia, did not decline in pigs treated by the specific neuropeptide Y2-receptor antagonist BIIE0246.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arginine / analogs & derivatives*
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Arginine / blood
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Arginine / pharmacology
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Benzazepines / blood
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Benzazepines / pharmacology*
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Biomarkers / blood
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Blood Pressure / drug effects
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Body Temperature / drug effects
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Carbon Dioxide / analysis
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Carbon Dioxide / blood
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Cardiac Output / drug effects
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Coronary Circulation / drug effects
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Coronary Stenosis / complications
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Disease Models, Animal
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Female
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Heart Rate / drug effects
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Hematocrit
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Male
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Myocardial Reperfusion / adverse effects*
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Myocardial Reperfusion Injury / etiology
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Myocardial Reperfusion Injury / prevention & control
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Oxygen / analysis
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Oxygen / blood
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Potassium / blood
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Receptors, Neuropeptide Y / antagonists & inhibitors*
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Receptors, Neuropeptide Y / blood
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Swine
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Tachycardia, Ventricular / etiology
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Tachycardia, Ventricular / physiopathology
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Tachycardia, Ventricular / prevention & control
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Ventricular Fibrillation / etiology*
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Ventricular Fibrillation / physiopathology
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Ventricular Fibrillation / prevention & control*
Substances
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Benzazepines
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Biomarkers
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Receptors, Neuropeptide Y
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neuropeptide Y2 receptor
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Carbon Dioxide
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Arginine
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BIIE 0246
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Potassium
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Oxygen