Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone

J Neurol Neurosurg Psychiatry. 1975 Aug;38(8):771-5. doi: 10.1136/jnnp.38.8.771.

Abstract

Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-buryl ketone (CH3COCH2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / pathology
  • Environmental Exposure
  • Hexanones / metabolism
  • Hexanones / poisoning*
  • Ketones / poisoning*
  • Nerve Fibers, Myelinated / pathology
  • Occupational Diseases / chemically induced
  • Peripheral Nerves / pathology
  • Peripheral Nervous System Diseases / chemically induced*
  • Rats
  • Solvents / poisoning*

Substances

  • Hexanones
  • Ketones
  • Solvents
  • 2,5-hexanedione