Abstract
Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-buryl ketone (CH3COCH2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Axons / pathology
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Environmental Exposure
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Hexanones / metabolism
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Hexanones / poisoning*
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Ketones / poisoning*
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Nerve Fibers, Myelinated / pathology
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Occupational Diseases / chemically induced
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Peripheral Nerves / pathology
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Peripheral Nervous System Diseases / chemically induced*
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Rats
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Solvents / poisoning*
Substances
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Hexanones
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Ketones
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Solvents
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2,5-hexanedione