Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?

Transplant Proc. 1991 Dec;23(6):2846-9.

Authors

N H Sigal¹, F J Dumont, J J Siekierka, G Wiederrecht, S A Parent, L Brizuela

Affiliation

¹ Department of Immunology Research, Merck, Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

PMID: 1721295

No abstract available

Publication types

Review

MeSH terms

Amino Acid Isomerases / genetics
Amino Acid Isomerases / physiology
Animals
Carrier Proteins / genetics
Carrier Proteins / physiology*
Chromosome Deletion
Cyclosporine / pharmacology
Humans
Immunosuppressive Agents / pharmacology
Neurospora crassa / genetics
Peptidylprolyl Isomerase
Saccharomyces cerevisiae / genetics
Tacrolimus / metabolism
Tacrolimus / pharmacology*
Tacrolimus / toxicity
Tacrolimus Binding Proteins

Substances

Carrier Proteins
Immunosuppressive Agents
Cyclosporine
Amino Acid Isomerases
Tacrolimus Binding Proteins
Peptidylprolyl Isomerase
Tacrolimus