Comment on "A common genetic variant is associated with adult and childhood obesity"

Science. 2007 Jan 12;315(5809):187; author reply 187. doi: 10.1126/science.1129402.

Abstract

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

Publication types

  • Comment

MeSH terms

  • Adult
  • Body Mass Index*
  • Case-Control Studies
  • Child
  • Family
  • Female
  • France
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Male
  • Membrane Proteins / genetics*
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide*
  • White People

Substances

  • INSIG2 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins