Abstract
It is commonly thought that bacterial endotoxin such as lipopolysaccharide (LPS) causes sepsis. Authors argue that LPS is merely a disease marker. The real mechanism of sepsis lies in the Toll-like receptors that suppress sepsis caused by tissue injury or endotoxin. When Toll-like receptors' initial suppression role is overwhelmed, sepsis ensues.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Humans
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Models, Biological
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Sepsis / etiology*
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Sepsis / metabolism*
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Sepsis / physiopathology
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Systemic Inflammatory Response Syndrome / etiology
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Systemic Inflammatory Response Syndrome / metabolism
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Systemic Inflammatory Response Syndrome / physiopathology
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Toll-Like Receptors / genetics
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Toll-Like Receptors / metabolism
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Toll-Like Receptors / physiology