protLIMS is a web-based proteomics laboratory information management system. In February, we released version 1 of protLIMS, completed to the year one goal: The web-interface provides for recording of the biological material, protein mixture preparation, 2D-PAGE, gel image files and spot and plug mapping. Associated files may be uploaded and retrieved through the web-interface to the file system. In year two, protLIMS will be extended to accommodate mass spectrometric analyses and protein identification.