Abstract
The extraction of naturally-processed peptides from MHC class I glycoproteins has paved the way for a major advance in the understanding of the antigen processing pathway that ultimately induces cytotoxic T-cell responses. Here, Olaf Rötzschke and Kirsten Falk review these new developments and discuss their findings in terms of a novel hypothesis of MHC class-I-restricted processing.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Amino Acid Sequence
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Animals
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Antigen-Presenting Cells / immunology*
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Antigen-Presenting Cells / metabolism
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Antigens / immunology*
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Antigens / metabolism
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Antigens, Viral / immunology
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Antigens, Viral / metabolism
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Consensus Sequence
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Endopeptidases / metabolism
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Epitopes / chemistry
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Epitopes / immunology
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Graft Rejection / immunology
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Histocompatibility Antigens / immunology
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Histocompatibility Antigens / metabolism
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / immunology*
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Humans
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Immune Tolerance
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Models, Biological
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Models, Molecular
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Molecular Sequence Data
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Peptide Fragments / immunology*
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Peptide Fragments / metabolism
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Protein Conformation
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Antigens
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Antigens, Viral
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Epitopes
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Histocompatibility Antigens
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Histocompatibility Antigens Class I
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Peptide Fragments
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Endopeptidases