Effects of growth hormone and insulin-like growth factor I on muscle in mouse models of human growth disorders

Horm Res. 2006:66 Suppl 1:26-34. doi: 10.1159/000096620.

Abstract

The precise effects of growth hormone (GH) and insulin-like growth factor I (IGF-I) on muscle development and physiology are relatively unknown. Furthermore, there have been conflicting reports on the effects of GH/IGF-I on muscle. Distinguishing the direct effects of GH versus those of IGF-I is problematic, but animal models with altered GH/IGF-I action could help to alleviate some of the conflicting results and help to determine the independent actions of GH and IGF-I. The phenotypes of several mouse models, namely the GH receptor-gene-disrupted (GHR -/-) mouse and a variety of IGF-I -/- mice, are summarized, which ultimately will aid our understanding of this complex area.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Disease Models, Animal
  • Growth Disorders / pathology*
  • Growth Hormone / pharmacology*
  • Humans
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / pharmacology*
  • Mice
  • Mice, Knockout
  • Muscle Fibers, Skeletal / drug effects
  • Muscles / drug effects*

Substances

  • Carrier Proteins
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • somatotropin-binding protein