High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center

Linda L Han; Linda K McDougal; Rachel J Gorwitz; Kenneth H Mayer; Jean B Patel; Janet M Sennott; John L Fontana

doi:10.1128/JCM.02274-06

High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center

J Clin Microbiol. 2007 Apr;45(4):1350-2. doi: 10.1128/JCM.02274-06. Epub 2007 Feb 7.

Authors

Linda L Han¹, Linda K McDougal, Rachel J Gorwitz, Kenneth H Mayer, Jean B Patel, Janet M Sennott, John L Fontana

Affiliation

¹ State Laboratory Institute, 305 South St., Jamaica Plain, MA 02130, USA. linda.han@state.ma.us

Abstract

Individual or multiple resistance to clindamycin, tetracycline, erythromycin, levofloxacin, or mupirocin was detected in a large proportion of methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at an ambulatory health center in Boston. The clindamycin, tetracycline, and mupirocin resistance genes identified in these isolates are commonly associated with plasmids.

MeSH terms

Ambulatory Care Facilities
Anti-Bacterial Agents / pharmacology
Bacterial Typing Techniques
Boston
Clindamycin / pharmacology*
DNA Fingerprinting
DNA, Bacterial / genetics
Drug Resistance, Multiple, Bacterial*
Electrophoresis, Gel, Pulsed-Field
Female
Genotype
Humans
Male
Methicillin Resistance*
Plasmids / genetics
Staphylococcal Infections / microbiology
Staphylococcus aureus / classification
Staphylococcus aureus / drug effects*
Staphylococcus aureus / isolation & purification*
Tetracycline Resistance*

Substances

Anti-Bacterial Agents
DNA, Bacterial
Clindamycin