Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

J Magn Reson Imaging. 2007 Apr;25(4):667-80. doi: 10.1002/jmri.20866.

Abstract

Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis* / diagnosis
  • Atherosclerosis* / therapy
  • Contrast Media*
  • Diagnostic Imaging / methods*
  • Humans
  • Nanomedicine / methods*
  • Nanoparticles / therapeutic use*
  • Neovascularization, Pathologic / diagnosis

Substances

  • Contrast Media